Alternatives to HTS: Hit-Finding Approaches in the Medicinal Chemist’s Arsenal

High-throughput screening (HTS) remains a powerful weapon for hit identification; however, it is important to understand the alternative tools available for initiating a drug discovery program. Integration of hit identification approaches can maximize the chances of success.

Our scientists examine some of the complementary approaches to HTS from a chemist’s perspective. Learn how strategies such as knowledge-based design, in silico screening, and fragment screening have been successfully applied to real drug discovery programs.


  • Sam Mann, PhD, MChem, Principal Scientist, Medicinal Chemistry, Charles River