Strategies to Minimize Genetic Drift and Maximize Experimental Reproducibility in Mouse Research (English)

Inbreeding is a powerful method to reduce heterozygosity at every locus of the mouse genome, but genetic drift can and does occur, which can confound reproducibility of research.

Download this white paper to learn more about: 

  • What genetic drift is, why it impacts study results, and how quickly it can develop
  • Why genetic drift is more common in smaller colonies than larger ones
  • Published examples of where heritable phenotypic differences between substrains have arisen
  • How to limit genetic drift while promoting reproducibility and responsible animal use

Author: Janine Low-Marchelli, PhD, Senior Technical Information Scientist, The Jackson Laboratory